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Principal Project Manager

Date:  Jan 14, 2022

Maryland Heights, MO, United States

About Curium

Curium is the world’s largest nuclear medicine company with more than a century of industry experience. We develop, manufacture and distribute world-class radiopharmaceutical products to help patients around the globe. Our proven heritage combined with a pioneering approach are the hallmarks to deliver innovation, excellence and unparalleled service.


With manufacturing facilities across Europe and the United States, Curium delivers SPECT, PET and therapeutic radiopharmaceutical solutions for life-threatening diseases to over 14 million patients annually. The name ‘Curium’ honors the legacy of pioneering radioactive researchers Marie and Pierre Curie, after whom the radioactive element curium was named and emphasizes our focus on nuclear medicine. The tagline ‘Life Forward’ represents our commitment to securing a brighter future for all those we serve: An enhanced quality of care for our patients. A trusted partner to our customers. A supportive employer to our valued team.


Summary of Position

The Principal Project Manager – Site CapEx Projects will report to the Director of Engineering.  The Principal Project Manager maintains complete cross-functional responsibility for facilitating and managing completion of all required elements of the project strategy. The Principal Project Manager works in collaboration with the Director of Engineering  and is responsible for assuring that the team members from all disciplines are completing the identified tasks.

Essential Functions

  • Support and/or lead the most critical and complex cross-functional projects and project teams with minimal outside support.
  • Responsible for establishing and managing the project scope, critical path and budget.
  • Perform detailed risk and financial analyses to identify and present the best project portfolio alternatives to the executive committee.
  • Utilize project management tools, software and best practices to quickly move projects from scoping to implementation.
  • Provide and maintain forecast estimates for project related costs and general project task tracking for adherence to project milestone goals.
  • Maintain complete cross-functional responsibility for facilitating and managing completion of all required elements of the project strategy including Marketing, Manufacturing, Quality, Logistics, Product Monitoring, Legal, Finance, Clinical and Regulatory.
  • Understanding of cost accounting related to product development, must understand intermediate accounting terminology and practical usage such as budget adherence, forecasting, accruals, reversals, plan vs actuals, NPV, IRR, EBITDA, and Free Cash Flow.
  • Develop the project Risk Management Plan including upsides, contingencies, and mitigations.
  • Demonstrates ability to mentor others and is seen as the “Go to Person” for challenging initiatives and technical advice.  
  • Estimates resources and timing while creating project development plans and negotiates team assignments with functional managers.
  • Develops the project schedule with the core team and establishes stakeholder buy-in to key milestones. Ensures PERT analysis is conducted on schedule and cost to obtain probability and sensitivity analysis when presenting the schedule to management.
  • Effectively facilitates and manages team meetings and assures that proper communication regarding the project is appropriately elevated and distributed (including presenting at key project stage and other reviews).


  • Bachelor Degree in Chemistry, Engineering or related field. Advanced degree preferred.  
  • PMP certification or related project management certificate / coursework required. 
  • 10 years project management experience in the pharmaceutical industry required.  This should include clinical trials and working in a multifunctional team environment. Experience in the radiopharmaceutical industry and operations preferred.
  • Technical understanding of the pharmaceutical development process from concept to launch; preferably in finished dosage products.
  • Knowledge / experience in aseptic / terminally sterile operations; isolator technology, tech transfer and scale up techniques with experience in manufacturing operations preferred.
  • Expert in project management tools and best practices, strong project management and organizational skills, including ability to work independently and as a team member.
  • Advanced knowledge of FDA Pharmaceutical Guidelines and Submission Requirements.
  • Ability to effectively handle conflict through proactive action and direct and timely communication.
  • Demonstrated attention to detail and experience to check behind the scenes to ensure surprises are minimized.
  • Proven ability in setting priorities and organizing work to meet deadlines. Strong organizational and planning skills.
  • Proven experience in leading complex multi-discipline project teams in a highly regulated environment.
  • Ability to react to problems and lead the team to develop solutions while communicating effectively to the executive team.
  • Ability to create PowerPoint presentations to senior leadership on a regular basis.  
  • Proven track record of developing accurate project budgets and schedules and reporting them via various tracking mechanisms. 
  • Ability to maintain collaboration in a results driven environment. Skilled in leadership and collaboration abilities.
  • Experience managing outside contractors, to include developing a Statement of Work and Purchasing Agreement, financial and goal tracking, and ensuring contractors provide required deliverables on time.
  • Agile approach and willingness to learn new things – ability to work “on the fly” in a dynamic setting.
  • Excellent interpersonal skills with demonstrated ability to work within a global team.
  • Advanced skills with Microsoft Office (Excel, PowerPoint, SharePoint, Word), MS Project and Visio; experience with Smartsheet is preferred. 
  • Travel may be required up to 25% of the time.


Working Conditions:

  • Standard office environment, coupled with approximately 20% time in radiopharmaceutical manufacturing and laboratory environments.
  • Must be willing to wear a variety of personal protective equipment.  
  • Willingness to work in plant producing radioactive materials and requiring all employees to participate in safety programs designed to minimize potential and/or actual exposure levels.
  • Responsibilities also include the ability to lift, walk, bend, stoop, push, pull, reach, and climb stairs with or without accommodation.  
  • Must possess good hand-eye coordination.
  • May be required to work weekends and holidays to support operations. 
  • Some gowning may be required to enter laboratory areas.


The above statements are intended to describe the general nature and level of work being performed by employees assigned to this classification. They are not intended to be construed as an exhaustive list of all responsibilities, duties and skills required of employees assigned to this position.


Equal Opportunity Employer

Curium is an equal opportunity employer and believes everyone deserves respect, dignity and equality.  All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.


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